Article
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
The American journal of pathology - 1 Aug 1993
Hruban R H, van Mansfeld A D, Offerhaus G J, van Weering D H, Allison D C, Goodman S N, Kensler T W, Bose K K, Cameron J L, Bos J L
Abstract excerpt
We examined 82 surgically resected or biopsied, formalin-fixed, paraffin-embedded primary adenocarcinomas of the pancreas for the presence of activating point mutations in codon 12 of the K-ras oncogene. Mutations were detected using primer-mediated, mutant-enriched, polymerase chain reaction-restriction fragment length polymorphism analysis and characterized further by allele-specific oligonucleotide...
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