Article
Human metapneumovirus G protein is highly conserved within but not between genetic lineages.
Archives of virology - 1 Jun 2013
Yang Chin-Fen, Wang Chiaoyin K, Tollefson Sharon J, Lintao Linda D, Liem Alexis, Chu Marla, Williams John V
Abstract excerpt
Human metapneumovirus (HMPV) is an important cause of acute respiratory illnesses in children. HMPV encodes two major surface glycoproteins, fusion (F) and glycoprotein (G). The function of G has not been fully established, though it is dispensable for in vitro and in vivo replication. We analyzed 87 full-length HMPV G sequences from isolates collected over 20 years. The G sequences fell into four subgroups with...
Topics
- Amino Acid Sequence
- Base Sequence
- Child, Preschool
- Conserved Sequence
- Genetic Variation
- Glycoproteins
- Humans
- Metapneumovirus
- Paramyxoviridae Infections
- Phylogeny
- Real-Time Polymerase Chain Reaction