Article

Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F protein

2021-05-19

Abstract excerpt

Human metapneumovirus (hMPV) is an important cause of acute viral respiratory infection. As the only target of neutralizing antibodies, the hMPV fusion (F) protein has been a major focus for vaccine development and targeting by drugs and monoclonal antibodies (mAbs). While X-ray structures of trimeric pre-fusion and post-fusion hMPV F proteins from genotype A, and monomeric pre-fusion hMPV F protein from genotype...

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Literature Corpus work: 3a8e7dfc-5d98-5d16-ad24-bf7a49f05c68
DOI: 10.1101/2021.05.19.444868

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