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Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein

10 Nov 2017

Abstract excerpt

Human metapneumovirus (hMPV) is a frequent cause of bronchiolitis in young children. Its F glycoprotein mediates virus-cell membrane fusion and is the primary target of neutralizing antibodies. The inability to produce recombinant hMPV F glycoprotein in the metastable pre-fusion conformation has hindered structural and immunological studies. Here, we engineer a pre-fusion-stabilized hMPV F ectodomain and...

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PMID: 29142300
DOI: 10.1038/s41467-017-01708-9

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