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Article

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.

Nature - 12 Dec 2002

Ko Hyuk Wan, Jiang Jin, Edery Isaac

Abstract excerpt

Protein phosphorylation has a key role in modulating the stabilities of circadian clock proteins in a manner specific to the time of day. A conserved feature of animal clocks is that Period (Per) proteins undergo daily rhythms in phosphorylation and levels, events that are crucial for normal clock progression. Casein kinase Iepsilon (CKIepsilon) has a prominent role in regulating the phosphorylation and abundance...

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Identifiers

PMID: 12442174
DOI: 10.1038/nature01272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.PMID 12442174Read ↗

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

The F-box protein slimb controls the levels of clock proteins period and timeless.Semantic proximity Read ↗

Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.Semantic proximity Read ↗

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.Semantic proximity Read ↗

PERspective on PER phosphorylation.Semantic proximity Read ↗

YIPPEE/YPEL5 regulates circadian period by modulating PER ubiquitination and stabilitySemantic proximity Read ↗

Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.Semantic proximity Read ↗

Activating PER repressor through a DBT-directed phosphorylation switch.Semantic proximity Read ↗

A role for casein kinase 2alpha in the Drosophila circadian clock.Semantic proximity Read ↗

The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensationSemantic proximity Read ↗

Casein kinase 1 promotes synchrony of the circadian clock network.Semantic proximity Read ↗

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