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Article

The F-box protein slimb controls the levels of clock proteins period and timeless.

Nature - 14 Nov 2002

Grima Brigitte, Lamouroux Annie, Chélot Elisabeth, Papin Christian, Limbourg-Bouchon Bernadette, Rouyer François

Abstract excerpt

The Drosophila circadian clock is driven by daily fluctuations of the proteins Period and Timeless, which associate in a complex and negatively regulate the transcription of their own genes. Protein phosphorylation has a central role in this feedback loop, by controlling Per stability in both cytoplasmic and nuclear compartments as well as Per/Tim nuclear transfer. However, the pathways regulating degradation of...

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PMID: 12432393
DOI: 10.1038/nature01122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The F-box protein slimb controls the levels of clock proteins period and timeless.PMID 12432393Read ↗

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.Semantic proximity Read ↗

PERspective on PER phosphorylation.Semantic proximity Read ↗

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

YIPPEE/YPEL5 regulates circadian period by modulating PER ubiquitination and stabilitySemantic proximity Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythmsSemantic proximity Read ↗

Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.Semantic proximity Read ↗

A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM.Semantic proximity Read ↗

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