Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain].

Genetika - 1 Dec 2007

Kulikov A V, Osipova D V, Popova N K

Abstract excerpt

Brain neurotransmitter serotonin is involved in the regulation of many physiological functions and types of behavior. The key enzyme of serotonin synthesis in the brain is tryptophan hydroxylase-2 (TPH-2). An association of the C1473G polymorphism in gene tph2 causing the replacement of Pro447 by Arg447 in TPH-2 molecule with enzyme activity in the mouse brain of 10 inbred strains was found. Association of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Brain
Share to Brain Chemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Nerve Tissue Proteins

Share to Polymorphism, Single Nucleotide

Share to Tryptophan Hydroxylase

Source

Identifiers

PMID: 18592694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain].PMID 18592694Read ↗

The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains.Semantic proximity Read ↗

Tryptophan hydroxylase-2 controls brain serotonin synthesis.Semantic proximity Read ↗

C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test.Semantic proximity Read ↗

Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice.Semantic proximity Read ↗

The C1473G polymorphism in the Tryptophan hydroxylase-2 gene: involvement in ethanol-related behavior in mice.Semantic proximity Read ↗

Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains.Semantic proximity Read ↗

The C1473G Mutation in the Mouse Tph2 Gene: From Molecular Mechanism to Biological Consequences.Semantic proximity Read ↗

Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice.Semantic proximity Read ↗

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Semantic proximity Read ↗

Role of TPH-2 in brain function: news from behavioral and pharmacologic studies.Semantic proximity Read ↗

C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress.Semantic proximity Read ↗

Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.