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Article

Tryptophan hydroxylase-2 controls brain serotonin synthesis.

Science (New York, N.Y.) - 9 Jul 2004

Zhang Xiaodong, Beaulieu Jean-Martin, Sotnikova Tatyana D, Gainetdinov Raul R, Caron Marc G

Abstract excerpt

Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro447 with Arg447 and leads to decreased serotonin levels in PC12 cells. Moreover, in BALB/cJ and DBA/2 mice that are homozygous for...

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Identifiers

PMID: 15247473
DOI: 10.1126/science.1097540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tryptophan hydroxylase-2 controls brain serotonin synthesis.PMID 15247473Read ↗

[The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain].Semantic proximity Read ↗

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Semantic proximity Read ↗

Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.Semantic proximity Read ↗

Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice.Semantic proximity Read ↗

The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains.Semantic proximity Read ↗

Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin.Semantic proximity Read ↗

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read ↗

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2Semantic proximity Read ↗

C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test.Semantic proximity Read ↗

Role of TPH-2 in brain function: news from behavioral and pharmacologic studies.Semantic proximity Read ↗

No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice.Semantic proximity Read ↗

The C1473G Mutation in the Mouse Tph2 Gene: From Molecular Mechanism to Biological Consequences.Semantic proximity Read ↗

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