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The C1473G Mutation in the Mouse Tph2 Gene: From Molecular Mechanism to Biological Consequences.

Biomolecules - 21 Mar 2025

Khotskin Nikita V, Komleva Polina D, Arefieva Alla B, Moskaliuk Vitalii S, Khotskina Anna, Alhalabi Ghofran, Izyurov Arseniy E, Sinyakova Nadezhda A, Sherbakov Daniil, Kulikova Elizabeth A, Bazovkina Daria V, Kulikov Alexander V

Abstract excerpt

Tryptophan hydroxylase 2 (TPH2) hydroxylates L-tryptophan to L-5-hydroxy tryptophan-the key step of 5-HT synthesis in the mammalian brain. Some mutations in the human hTPH2 gene are associated with psychopathologies and resistance to antidepressant therapy. The C1473G polymorphism in the mouse Tph2 gene decreases the TPH2 activity in the mouse brain. In the present paper, B6-1473C and B6-1473G congenic mice that...

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Identifiers

PMID: 40305154
DOI: 10.3390/biom15040461
PMCID: PMC12024906

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TPH2

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