The C1473G polymorphism in the Tryptophan hydroxylase-2 gene: involvement in ethanol-related behavior in mice.

doi:10.1016/j.neulet.2015.01.043

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Article

The C1473G polymorphism in the Tryptophan hydroxylase-2 gene: involvement in ethanol-related behavior in mice.

Neuroscience letters - 4 Mar 2015

Bazovkina Darya V, Lichman Daria V, Kulikov Alexander V

Abstract excerpt

Tryptophan hydroxylase-2 (Tph2) is the rate limiting enzyme of serotonin synthesis in the brain. The functional (C1473G) polymorphism in the mouse Tph2 gene affecting the enzymatic activity was suspected to be involved in behavioral actions of ethanol (EtOH). Congenic B6-1473C (C/C) and B6-1473G (G/G) lines bred from C57BL/6 mice were not different in EtOH-induced sleep time and hypothermia. B6-1473C mice...

Topics

Animals
Body Temperature
Crosses, Genetic
Ethanol
Genotype
Locomotion
Male
Mice, Inbred C57BL
Polymorphism, Genetic
Sleep
Tryptophan Hydroxylase

Source

Open in PubMed

Identifiers

PMID: 25603476
DOI: 10.1016/j.neulet.2015.01.043

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