Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress.

Neuroscience letters - 15 Feb 2017

Bazhenova Ekaterina Y, Bazovkina Daria V, Kulikova Elizabeth A, Fursenko Dariya V, Khotskin Nikita V, Lichman Daria V, Kulikov Alexander V

Abstract excerpt

Neurotransmitter serotonin (5-HT) is involved in the regulation of stress response. Tryptophan hydroxylase-2 (TPH2) is the key enzyme of serotonin (5-HT) synthesis in the brain. C1473G polymorphism in Tph2 gene is the main factor defining the enzyme activity in the brain of laboratory mice. The effect of interaction between C1473G polymorphism and 30min restriction stress on the behavior in the open field test,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Hydroxyindoleacetic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Proto-Oncogene Proteins c-fos

Share to RNA, Messenger

Share to Serotonin

Share to Stress, Psychological

Share to Tryptophan Hydroxylase

Source

Identifiers

PMID: 28069454
DOI: 10.1016/j.neulet.2017.01.010

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress.PMID 28069454Read ↗

C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test.Semantic proximity Read ↗

The C1473G polymorphism in the Tryptophan hydroxylase-2 gene: involvement in ethanol-related behavior in mice.Semantic proximity Read ↗

No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice.Semantic proximity Read ↗

Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice.Semantic proximity Read ↗

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Semantic proximity Read ↗

[The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain].Semantic proximity Read ↗

Tryptophan hydroxylase-2 controls brain serotonin synthesis.Semantic proximity Read ↗

The C1473G Mutation in the Mouse Tph2 Gene: From Molecular Mechanism to Biological Consequences.Semantic proximity Read ↗

Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice.Semantic proximity Read ↗

Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice.Semantic proximity Read ↗

Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease.Semantic proximity Read ↗

The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.