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Article

Role of TPH-2 in brain function: news from behavioral and pharmacologic studies.

Journal of neuroscience research - 1 Nov 2007

Invernizzi Roberto W

Abstract excerpt

The recent discovery of TPH-2, a new isoform of tryptophan hydroxylase, the enzyme that catalyses the transformation of tryptophan into 5-hydroxytryptophan and the rate-limiting step in brain serotonin (5-HT) biosynthesis, has boosted new interest in the many functions of 5-HT in the brain and non-nervous tissues. Recent studies on TPH-2 are reviewed with particular attention to the role of this enzyme in...

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Identifiers

PMID: 17492791
DOI: 10.1002/jnr.21330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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