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Article

Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.

Neuroscience letters - 30 Aug 2010

Siesser William B, Zhang Xiaodong, Jacobsen Jacob P R, Sotnikova Tatyana D, Gainetdinov Raul R, Caron Marc G

Abstract excerpt

Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in the synthesis of brain serotonin (5-HT). In a previous report, a single nucleotide polymorphism in mTph2 (C1473G) reduced 5-HT synthesis by 55%. Mouse strains expressing the 1473C allele, such as C57Bl/6, have higher 5-HT synthesis rates than strains expressing the 1473G allele, such as BALB/c. Many studies have attributed strain differences to...

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Identifiers

PMID: 20600620
DOI: 10.1016/j.neulet.2010.06.035
PMCID: PMC2933733

Genes

TPH2

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