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Article

Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression.

The pharmacogenomics journal - 1 Jun 2013

Duarte J D, Turner S T, Tran B, Chapman A B, Bailey K R, Gong Y, Gums J G, Langaee T Y, Beitelshees A L, Cooper-Dehoff R M, Boerwinkle E, Johnson J A

Abstract excerpt

A recent genome-wide analysis discovered an association between a haplotype (from rs317689/rs315135/rs7297610) on Chromosome 12q15 and blood pressure response to hydrochlorothiazide (HCTZ) in African-Americans. Our aim was to replicate this association and investigate possible functional mechanisms. We observed similar associations between this haplotype and HCTZ response in an independent sample of 746...

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Source

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Identifiers

PMID: 22350108
DOI: 10.1038/tpj.2012.4
PMCID: PMC3360116

Genes

YEATS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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