Article
Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide.
The pharmacogenomics journal - 1 Apr 2015
Del-Aguila J L, Cooper-DeHoff R M, Chapman A B, Gums J G, Beitelshees A L, Bailey K, Turner S T, Johnson J A, Boerwinkle E
Abstract excerpt
Hypokalemia is a recognized adverse effect of thiazide diuretic treatment. This phenomenon, which may impair insulin secretion, has been suggested to be a reason for the adverse effects on glucose metabolism associated with thiazide diuretic treatment of hypertension. However, the mechanisms underlying thiazide diuretic-induced hypokalemia are not well understood. In an effort to identify genes or genomic regions...
Topics
- Black or African American
- Antihypertensive Agents
- Bayes Theorem
- Carrier Proteins
- Cation Transport Proteins
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 8
- Female
- Genome-Wide Association Study