Article
Genetic and environmental modulations of chromosomal stability: their roles in aging and oncogenesis.
Annals of the New York Academy of Sciences - 1 Jan 1991
Martin G M
Abstract excerpt
The primary objective of this review is to suggest a major role of cytogenetic pathology in the genesis of both the neoplastic phenotype and the senescent phenotype of aging mammalian organisms. It is hypothesized that allelic variation at a number of genetic loci that have the potential to modul...
Topics
- Aging
- Animals
- Carcinogens
- Chromosome Aberrations
- Chromosome Disorders
- Free Radicals
- Humans
- Mutation
- Neoplasms