Article
A review and appraisal of the DNA damage theory of ageing.
Mutation research - 1 Jan 2000
Freitas Alex A, de Magalhães João Pedro
Abstract excerpt
Given the central role of DNA in life, and how ageing can be seen as the gradual and irreversible breakdown of living systems, the idea that damage to the DNA is the crucial cause of ageing remains a powerful one. DNA damage and mutations of different types clearly accumulate with age in mammalian tissues. Human progeroid syndromes resulting in what appears to be accelerated ageing have been linked to defects in...
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