Article
Circadian tempo: a paradigm for genome stability?
Medical hypotheses - 1 Jan 2007
Shadan Farhad F
Abstract excerpt
Circadian clocks are molecular time-keeping systems that underlie daily biological rhythms in anticipation of the changing light and dark cycles. These clocks mediate daily rhythms in physiology and behavior that are thought to confer an adaptive advantage for organisms. It is hypothesized that cell cycle checkpoints are gated to an intrinsic circadian clock to protect DNA from diurnal exposure to mutagens (e.g.;...
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