Somatic cell mutations: can they provide a link between aging and cancer?

Abstract excerpt

Cancers increase during aging in mammals, and an accumulating body of evidence suggests that mutational events too do likewise. Mutational events are intimately involved in the malignant process. One current view is that mutator phenotypes are required in malignant cells for a sufficient number of critical target genes to be affected. These mutator phenotypes are believed to result from underlying deficiencies in...

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