Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Measuring genome instability in aging - a mini-review.

Gerontology - 1 Jan 2012

Li Wenge, Vijg Jan

Abstract excerpt

BACKGROUND: There is mounting evidence for an age-dependent accumulation of somatic mutations as a result of the inherent imperfection of DNA replication and repair. A possible age-related decline in genome maintenance systems may exacerbate this age-related loss of genome integrity. A review of the current methods of mutation detection is timely in view of the lack of insight as to the magnitude of somatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Aneuploidy
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Repair

Share to Genes, Reporter

Share to Genomic Instability

Share to Models, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22156741
DOI: 10.1159/000334368
PMCID: PMC3696364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Measuring genome instability in aging - a mini-review.PMID 22156741Read ↗

Genome instability and aging: Cause or effect?Semantic proximity Read ↗

Genome instability and aging.Semantic proximity Read ↗

Mitigating age-related somatic mutation burden.Semantic proximity Read ↗

Somatic mutations in aging and disease.Semantic proximity Read ↗

Genome instability: a conserved mechanism of ageing?Semantic proximity Read ↗

Genome instability, cancer and aging.Semantic proximity Read ↗

Mutation accumulation in vivo and the importance of genome stability in aging and cancer.Semantic proximity Read ↗

Challenges of proving a causal role of somatic mutations in the aging process.Semantic proximity Read ↗

Genome Instability and DNA Repair in Somatic and Reproductive Aging.Semantic proximity Read ↗

Somatic mutations, genome mosaicism, cancer and aging.Semantic proximity Read ↗

Endogenous DNA Damage as a Source of Genomic Instability in Cancer.Semantic proximity Read ↗

Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.