Article
Genetic modulation of senescent phenotypes in Homo sapiens.
Cell - 25 Feb 2005
Martin George M
Abstract excerpt
Single-gene mutations can produce human progeroid syndromes--phenotypes that mimic usual or "normative" aging. These can be divided into two classes--those that have their impacts upon multiple organs and tissues (segmental progeroid syndromes) and those that have their major impacts upon a single organ or tissue (unimodal progeroid syndromes). The prototypic example of the former is the Werner syndrome, a...
Topics
- Aging
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Ataxia Telangiectasia
- Diabetes Mellitus, Lipoatrophic
- Humans
- Mutation
- Myotonic Dystrophy
- Phenotype
- Progeria
- Werner Syndrome