Article
Nuclear Genomic Instability and Aging.
Annual review of biochemistry - 20 Jun 2018
Niedernhofer Laura J, Gurkar Aditi U, Wang Yinsheng, Vijg Jan, Hoeijmakers Jan H J, Robbins Paul D
Abstract excerpt
The nuclear genome decays as organisms age. Numerous studies demonstrate that the burden of several classes of DNA lesions is greater in older mammals than in young mammals. More challenging is proving this is a cause rather than a consequence of aging. The DNA damage theory of aging, which argues that genomic instability plays a causal role in aging, has recently gained momentum. Support for this theory stems...
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