Back to search

Article

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2

2019-03-14

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Sex differences in the incidence and progression of many liver diseases, including liver fibrosis and hepatocellular carcinoma, are associated with sex-biased expression of hundreds of genes in the liver. This sexual dimorphism is largely determined by the sex-specific pattern of pituitary growth hormone secretion, which controls a transcriptional regulatory network operative...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
68b100e2-0e48-5a84-9eac-d564b6428c1e
DOI
10.1101/577056
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2DOI 10.1101/577056
Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin StatesSemantic proximity
Epigenetic Regulation of Cell-Fate Changes That Determine Adult Liver Regeneration After InjurySemantic proximity
Unraveling the Epigenetic Basis of Liver Development, Regeneration and DiseaseSemantic proximity
Harnessing natural variation to identify <i>cis</i> regulators of sex-biased gene expression in a multi-strain mouse liver modelSemantic proximity
Plasma Growth Hormone Pulses Induce Male-biased Pulsatile Chromatin Opening and Epigenetic Regulation in Adult Mouse LiverSemantic proximity
Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.Semantic proximity
Plasma growth hormone pulses induce male-biased pulsatile chromatin opening and epigenetic regulation in adult mouse liverSemantic proximity
Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytesSemantic proximity
Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery DiseaseSemantic proximity
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred miceSemantic proximity
Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver.Semantic proximity
Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse LiverSemantic proximity
Select a neighboring publication to make it the new centre.