Article

Pathological LSD1 mutations repress enhancer-mediated gene regulatory networks in early differentiation

2021-08-11

Abstract excerpt

Lysine-specific demethylase 1 (LSD1/KDM1A) demethylates both histone and non-histone substrates, recruits repressive chromatin complexes, and is increased in cancers. De novo LSD1 mutations impairing protein function lead to a rare developmental disorder, but the molecular details of the pathology remains unclear. Using patient-derived fibroblasts, reprogrammed pluripotent stem cells, and differentiated cells, we...

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Literature Corpus work: b03b1a38-5542-5b4e-ba5d-6825bfad9837
DOI: 10.1101/2021.08.11.455900

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