Article
[Association of fragile histidine triad gene (FHIT) with susceptibility to esophageal cancer. A preliminary study].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Jul 1998
Li W, Wang X, Cheng G
Abstract excerpt
OBJECTIVE: To identify loss of heterozygosity(LOH) and homozygous deletion on loci of fragile histidine triad gene(FHIT). METHODS: Gene regions have been detected in 73 pairs of esophageal cancer samples using microsatellite DNA markers. Deletions of FHIT cDNA on 14 fresh esophageal cancer(EC) samples and 2 EC cell lines were screened by RT-PCR and DNA sequencing. RESULTS: High frequency of LOH was detected on...
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