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Article

Down-regulation of FHIT inhibits apoptosis of colorectal cancer: mechanism and clinical implication.

Surgical oncology - 1 Dec 2006

Cao Jie, Li Wanglin, Xie Jie, Du Hong, Tang Weibiao, Wang Hui, Chen Xiwen, Xiao Wanqing, Li Yuyuan

Abstract excerpt

Fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in carcinogenesis of many human tissues, including digestive tract tissues. However, the expression and role of FHIT in the initiation and the development of the colorectal cancer (CRC) are poorly understood. In our present study, we have demonstrated that the FHIT gene exhibits significantly...

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Source

Identifiers

PMID: 17382535
DOI: 10.1016/j.suronc.2007.01.006

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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