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Article

Molecular basis of drug resistance in aurora kinases.

Chemistry & biology - 1 Jun 2008

Girdler Fiona, Sessa Fabio, Patercoli Simona, Villa Fabrizio, Musacchio Andrea, Taylor Stephen

Abstract excerpt

Aurora kinases have emerged as potential targets in cancer therapy, and several drugs are currently undergoing preclinical and clinical validation. Whether clinical resistance to these drugs can arise is unclear. We exploited a hypermutagenic cancer cell line to select mutations conferring resistance to a well-studied Aurora inhibitor, ZM447439. All resistant clones contained dominant point mutations in Aurora B....

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Identifiers

PMID: 18559266
DOI: 10.1016/j.chembiol.2008.04.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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