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Article

A computational model for overcoming drug resistance using selective dual-inhibitors for aurora kinase A and its T217D variant.

Molecular pharmaceutics - 2 Dec 2013

Barakat Khaled H, Huzil J Torin, Jordan Kirk E, Evangelinos Constantinos, Houghton Michael, Tuszynski Jack

Abstract excerpt

The human Aurora kinase-A (AK-A) is an essential mitotic regulator that is frequently overexpressed in several cancers. The recent development of several novel AK-A inhibitors has been driven by the well-established association of this target with cancer development and progression. However, resi...

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PMID: 24094068
DOI: 10.1021/mp4003893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24094068-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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