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Article

Evolutionary relationships of Aurora kinases: Implications for model organism studies and the development of anti-cancer drugs

12 Oct 2004

Abstract excerpt

BACKGROUND: As key regulators of mitotic chromosome segregation, the Aurora family of serine/threonine kinases play an important role in cell division. Abnormalities in Aurora kinases have been strongly linked with cancer, which has lead to the recent development of new classes of anti-cancer drugs that specifically target the ATP-binding domain of these kinases. From an evolutionary perspective, the species...

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PMID: 15476560
DOI: 10.1186/1471-2148-4-39

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