Article
Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237.
ACS chemical biology - 18 Jun 2010
Sloane Dominic A, Trikic Michael Z, Chu Matthew L H, Lamers Maria B A C, Mason Clive S, Mueller Ilka, Savory Wendy J, Williams David H, Eyers Patrick A
Abstract excerpt
The Aurora kinases regulate multiple aspects of mitotic progression, and their overexpression in diverse tumor types makes them appealing oncology targets. An intensive research effort over the past decade has led to the discovery of chemically distinct families of small molecule Aurora kinase inhibitors, many of which have demonstrated therapeutic potential in model systems. These agents are also important tools...
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