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Aurora kinase inhibitors: Progress towards the clinic

17 Feb 2012

Abstract excerpt

The Aurora kinases (serine/threonine kinases) were discovered in 1995 during studies of mutant alleles associated with abnormal spindle pole formation in Drosophila melanogaster. They soon became the focus of much attention because of their importance in human biology and association with cancer. Aurora kinases are essential for cell division and are primarily active during mitosis. Following their identification...

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PMID: 22350019
DOI: 10.1007/s10637-012-9798-6

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