Validating Aurora B as an anti-cancer drug target.

Abstract excerpt

The Aurora kinases, a family of mitotic regulators, have received much attention as potential targets for novel anti-cancer therapeutics. Several Aurora kinase inhibitors have been described including ZM447439, which prevents chromosome alignment, spindle checkpoint function and cytokinesis. Subsequently, ZM447439-treated cells exit mitosis without dividing and lose viability. Because ZM447439 inhibits both...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aurora Kinase B
• Share to Aurora Kinases
• Share to Benzamides