Article
A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo.
Blood - 15 Sept 2008
Okada Yoshiaki, Jin Enjing, Nikolova-Krstevski Vesna, Yano Kiichiro, Liu Ju, Beeler David, Spokes Katherine, Kitayama Mie, Funahashi Nobuaki, Doi Takefumi, Janes Lauren, Minami Takashi, Oettgen Peter, Aird William C
Abstract excerpt
We recently demonstrated that the 3-kb 5'-flanking region of the human ROBO4 gene directs endothelial cell-specific expression in vitro and in vivo. Moreover, a GA-binding protein (GABP)-binding motif at -119 was necessary for mediating promoter activity in vitro. The goal of the present study was to confirm the functional relevance of the -119 GABP-binding site in vivo. To that end, the Hprt locus of mice was...
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