Article
Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo.
Blood - 24 Dec 2009
Jin Enjing, Liu Ju, Suehiro Jun-Ichi, Yuan Lei, Okada Yoshiaki, Nikolova-Krstevski Vesna, Yano Kiichiro, Janes Lauren, Beeler David, Spokes Katherine C, Li Dan, Regan Erzsébet, Shih Shou-Ching, Oettgen Peter, Minami Takashi, Aird William C
Abstract excerpt
Vascular endothelial growth factor receptor 1 (VEGFR1) is a marker for endothelial-specific gene expression. We previously reported that the human VEGFR1 promoter (between -748 and +284) contains information for expression in the intact endothelium of transgenic mice. The objective of this study was to dissect the cis-regulatory elements underlying VEGFR1 promoter activity in vitro and in vivo. In primary...
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