Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression.

Blood - 25 Aug 2011

Yang Zhong-Fa, Drumea Karen, Cormier James, Wang Junling, Zhu Xuejun, Rosmarin Alan G

Abstract excerpt

GABP is an ets transcription factor that regulates genes that are required for myeloid differentiation. The tetrameric GABP complex includes GABPα, which binds DNA via its ets domain, and GABPβ, which contains the transcription activation domain. To examine the role of GABP in myeloid differentiation, we generated mice in which Gabpa can be conditionally deleted in hematopoietic tissues. Gabpa knockout mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to CD11b Antigen
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockout Techniques

Share to Mice, Knockout

Share to Myelopoiesis

Share to Precursor Cells, B-Lymphoid

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21705494
DOI: 10.1182/blood-2010-07-298802
PMCID: PMC3162354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression.PMID 21705494Read ↗

GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia.Semantic proximity Read ↗

Transcription Factor GFI1B in Health and DiseaseSemantic proximity Read ↗

Maturation stage–specific regulation of megakaryopoiesis by pointed-domain Ets proteinsSemantic proximity Read ↗

Gfi-1 Oncoproteins in HematopoiesisSemantic proximity Read ↗

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.Semantic proximity Read ↗

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formationSemantic proximity Read ↗

Gfi1–cells and circuits: unraveling transcriptional networks of development and diseaseSemantic proximity Read ↗

Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesisSemantic proximity Read ↗

Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cellsSemantic proximity Read ↗

Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.Semantic proximity Read ↗

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.Semantic proximity Read ↗

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.