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Article

Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice.

9 May 1995

Abstract excerpt

The present study was undertaken to define the 5' and 3' regulatory sequences of human von Willebrand factor gene that confer tissue-specific expression in vivo. Transgenic mice were generated bearing a chimeric construct that included 487 bp of 5' flanking sequence and the first exon fused in-frame to the Escherichia coli lacZ gene. In situ histochemical analyses in independent lines demonstrated that the von...

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PMID: 7753844
DOI: 10.1073/pnas.92.10.4567

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