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Article

Hypoxia results in upregulation and de novo activation of von Willebrand factor expression in lung endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2013

Mojiri Anahita, Nakhaii-Nejad Maryam, Phan Wei-Lee, Kulak Stephen, Radziwon-Balicka Aneta, Jurasz Paul, Michelakis Evangelos, Jahroudi Nadia

Abstract excerpt

OBJECTIVE: Increased von Willebrand factor (VWF) levels in lungs are associated with diseases such as pulmonary hypertension. The objective of our study was to determine the mechanism of increased VWF levels in conditions, such as hypoxia, which contribute to pulmonary hypertension. APPROACH AND RESULTS: We have previously reported generation of transgenic mice that express LacZ transgene under the regulation of...

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Source

Identifiers

PMID: 23580145
DOI: 10.1161/ATVBAHA.113.301359

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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