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Article

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression.

Blood - 1 Mar 2000

Anderson K P, Crable S C, Lingrel J B

Abstract excerpt

The erythroid Krüppel-like factor (EKLF) is a key regulatory protein in globin gene expression. This zinc finger transcription factor is required for expression of the adult beta globin gene, and it has been suggested that it plays an important role in the developmental switch from fetal gamma to adult beta globin gene expression. We have previously described a sequence element in the distal promoter region of...

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PMID: 10688820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression.PMID 10688820Read ↗

Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.Semantic proximity Read ↗

Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.Semantic proximity Read ↗

Isolation, Genomic Structure, and Expression of Human Erythroid Krüppel-Like Factor (EKLF)Semantic proximity Read ↗

Loss of LKLF function results in embryonic lethality in mice.Semantic proximity Read ↗

Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.Semantic proximity Read ↗

Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene SwitchingSemantic proximity Read ↗

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.Semantic proximity Read ↗

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivoSemantic proximity Read ↗

Recombinant erythroid Kruppel-like factor fused to GATA1 up-regulates delta- and gamma-globin expression in erythroid cellsSemantic proximity Read ↗

The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.Semantic proximity Read ↗

Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.Semantic proximity Read ↗

Erythroid Kruppel‐like factor (EKLF) is recruited to the <i>γ</i>‐<i>globin</i> gene promoter as a co‐activator and is required for <i>γ</i>‐<i>globin</i> gene induction by short‐chain fatty acid derivativesSemantic proximity Read ↗

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