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Article

BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2017

Menendez Matthew T, Ong E-Ching, Shepherd Brian T, Muthukumar Vijay, Silasi-Mansat Robert, Lupu Florea, Griffin Courtney T

Abstract excerpt

OBJECTIVE: The chromatin remodeling enzyme BRG1 (brahma-related gene 1) transcriptionally regulates target genes important for early blood vessel development and primitive hematopoiesis. However, because Brg1 deletion in vascular progenitor cells results in lethal anemia by embryonic day 10.5 (E10.5), roles for BRG1 in embryonic vascular development after midgestation are unknown. In this study, we sought to...

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PMID: 28729363
DOI: 10.1161/ATVBAHA.117.309785
PMCID: PMC5570645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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