Article
Conserved GC-boxes, E-box and GATA motif are essential for GATA-4 gene expression in P19CL6 cells.
Biochemical and biophysical research communications - 23 Sept 2011
Ishibashi Takuya, Yokura Yumei, Ohashi Kazuaki, Yamamoto Hiroshi, Maeda Masatomo
Abstract excerpt
The promoter of the GATA-4 gene was analyzed in P19CL6 cells. A 124bp segment containing conserved two GC-boxes and E-box was essential for the basal promoter activity, as determined with a transient luciferase reporter gene assay. However, an extended 1312 bp reporter construct but not the 124 bp segment, when ligated to the GFP gene and stably inserted into the chromosome, showed regulated promoter activity...
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