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Article

Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability.

Archives of pathology & laboratory medicine - 1 Jun 2008

Kakar Sanjay, Deng Guoren, Sahai Vaibhav, Matsuzaki Koji, Tanaka Hirofumi, Miura Soichuro, Kim Young S

Abstract excerpt

CONTEXT: The 2 chief pathways implicated in colorectal carcinogenesis, microsatellite instability and chromosomal instability, are not present in 20% to 37% of cases. OBJECTIVE: To determine whether the CpG island methylator phenotype (CIMP) pathway, characterized by simultaneous methylation of several known tumor suppressor genes, is the principal underlying mechanism in cases without chromosomal or...

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Identifiers

PMID: 18517279
DOI: 10.5858/2008-132-958-CCCIMP

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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