Article
Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability.
Archives of pathology & laboratory medicine - 1 Jun 2008
Kakar Sanjay, Deng Guoren, Sahai Vaibhav, Matsuzaki Koji, Tanaka Hirofumi, Miura Soichuro, Kim Young S
Abstract excerpt
CONTEXT: The 2 chief pathways implicated in colorectal carcinogenesis, microsatellite instability and chromosomal instability, are not present in 20% to 37% of cases. OBJECTIVE: To determine whether the CpG island methylator phenotype (CIMP) pathway, characterized by simultaneous methylation of s...
Topics
- Aged
- Biomarkers, Tumor
- Chromosomal Instability
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- DNA Mutational Analysis
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Microsatellite Instability
- Middle Aged
- Mutation
- Phenotype