Article
[Chromosomal instability, microsatellite instability and CpG island methylator phenotype: roles in small intestinal carcinogenesis].
Der Pathologe - 1 Nov 2011
Bläker H, Warth A, Kloor M, Schirmacher P
Abstract excerpt
AIMS: Intestinal carcinogenesis is associated with genetic instability affecting either the chromosomal level (CIN) or microsatellite DNA sequences (MIN). In addition, epigenetic alterations, such as aberrant CpG island methylation (CIMP) may contribute to tumor development. While these single ge...
Topics
- Adenocarcinoma
- Cell Transformation, Neoplastic
- Chromosomal Instability
- CpG Islands
- DNA-Cytosine Methylases
- Humans
- Intestinal Neoplasms
- Microsatellite Instability
- Phenotype