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Article

Mechanism of 2-aminopurine-stimulated mutagenesis in Escherichia coli.

Mutation research - 4 Jun 2004

Pitsikas Photini, Patapas Jason M, Cupples Claire G

Abstract excerpt

2-Aminopurine (2AP), a base analog, causes both transition and frameshift mutations in Escherichia coli. The analog is thought to cause mutations by two mechanisms: directly, by mispairing with cytosine, and indirectly, by saturation of mismatch repair (MMR). The goal of this work was to measure the relative contribution of these two mechanisms to the occurrence of transition mutations. Our data suggest that, in...

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Identifiers

PMID: 15135638
DOI: 10.1016/j.mrfmmm.2004.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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