Article
In vitro plasmid-encoded resistance to quinolones.
FEMS microbiology letters - 15 Sept 1997
Gómez-Gómez J M, Blázquez J, Espinosa De Los Monteros L E, Baquero M R, Baquero F, Martínez J L
Abstract excerpt
The possibility of plasmid-encoded quinolone resistance is explored in two model systems. In the first, increasing amounts of wild-type gyrA allele moderately increased minimum inhibitory concentrations to quinolone antibiotics. In the second model, a mutant gyrA allele encoded by a multicopy pla...
Topics
- Alleles
- Anti-Infective Agents
- DNA Gyrase
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Escherichia coli
- Fluoroquinolones
- Gene Dosage
- Genetic Complementation Test
- Plasmids