Article
In vitro plasmid-encoded resistance to quinolones.
FEMS microbiology letters - 15 Sept 1997
Gómez-Gómez J M, Blázquez J, Espinosa De Los Monteros L E, Baquero M R, Baquero F, Martínez J L
Abstract excerpt
The possibility of plasmid-encoded quinolone resistance is explored in two model systems. In the first, increasing amounts of wild-type gyrA allele moderately increased minimum inhibitory concentrations to quinolone antibiotics. In the second model, a mutant gyrA allele encoded by a multicopy plasmid produced a quinolone resistance phenotype upon its expression in a quinolone-susceptible Escherichia coli strain.
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