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Article

Analysis of the NH2-terminal 83rd amino acid of Escherichia coli GyrA in quinolone-resistance.

Microbiology and immunology - 1 Jan 1995

Yonezawa M, Takahata M, Banzawa N, Matsubara N, Watanabe Y, Narita H

Abstract excerpt

Artificial mutations of Gyrase A protein (GyrA) in Escherichia coli by site-directed mutagenesis were generated to analyze quinolone-resistant mechanisms. By genetic analysis of gyrA genes in a gyrA temperature sensitive (Ts) background, exchange of Ser at the NH2-terminal 83rd position of GyrA to Trp, Leu, Phe, Tyr, Ala, Val, and Ile caused bacterial resistance to the quinolones, while exchange to Gly, Asn, Lys,...

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Identifiers

PMID: 7651238
DOI: 10.1111/j.1348-0421.1995.tb02196.x

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