Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems

Abstract excerpt

In summary, the available data indicate that most quinolones examined are not highly inhibitory for eucaryotic topoisomerases or other enzymes involved in DNA replication. Although a number of positive in vitro genotoxicity test results have been documented with several different 4-quinolones, the effective concentrations would be clinically achieved predominantly in the urinary tract (4, 5). It has been...

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