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Article

The role of the excision and error-prone repair systems in mutagenesis by fluorinated quinolones in Salmonella typhimurium.

Mutation research - 1 Mar 1992

Clerch B, Barbé J, Llagostera M

Abstract excerpt

Patterns of reversion produced by ciprofloxacin, enoxacin and ofloxacin in Salmonella typhimurium strains carrying the hisG428 ochre mutation have been studied. These fluorinated quinolones produce a significant increase in reversion of this mutation, even when it is located on the chromosome. Nevertheless, reversion is higher when the hisG428 mutation is on the multicopy plasmid pAQ1 than when it is on the...

Topics

Ciprofloxacin
DNA Repair
Dose-Response Relationship, Drug
Enoxacin
Genes, Bacterial
Genotype
Mutagenesis
Mutagenicity Tests
Mutagens
Ofloxacin
Salmonella typhimurium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1371844
DOI: 10.1016/0165-7992(92)90010-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1371844-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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