Article
Multiple ways of C/EBPalpha inhibition in myeloid leukaemia.
European journal of cancer (Oxford, England : 1990) - 1 Jul 2008
Trivedi A K, Pal P, Behre G, Singh S M
Abstract excerpt
Transcription factors play a crucial role in myeloid differentiation and lineage determination. Tumour suppressor protein C/EBPalpha is a key regulator of granulocytic differentiation whose functional inactivation has become a pathophysiological signature of myeloid leukaemia. In this review we describe various mechanisms such as antagonistic protein-protein interaction, mutation and posttranslational...
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