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Article

Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML.

Leukemia - 1 May 2010

Pulikkan J A, Dengler V, Peer Zada A A, Kawasaki A, Geletu M, Pasalic Z, Bohlander S K, Ryo A, Tenen D G, Behre G

Abstract excerpt

The transcription factor CCAAT enhancer-binding protein alpha (C/EBPalpha) has an important role in granulopoiesis. The tumor suppressor function of C/EBPalpha is shown by the findings that loss of expression or function of C/EBPalpha in leukemic blasts contributes to a block in myeloid cell differentiation and to leukemia. C/EBPalpha mutations are found in around 9% of acute myeloid leukemia (AML) patients. The...

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Identifiers

PMID: 20376080
DOI: 10.1038/leu.2010.37
PMCID: PMC2923485

Genes

PIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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