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Article

C/EBPalpha S248A mutation reduces granulocytic differentiation in human leukemic K562 cells.

Biochemical and biophysical research communications - 2 May 2008

Singh Sheo M, Trivedi A K, Behre Gerhard

Abstract excerpt

Phosphorylation of C/EBPalpha can either lead to granulocytic differentiation or a block in granulopoiesis. This dichotomy in effect is dependent on the upstream signaling pathway and the phosphorylation site in C/EBPalpha. Ras signaling induced phosphorylation of S248 residue of C/EBPalpha is known to enhance granulocytic differentiation. In this study, using beta-estradiol inducible stable cell lines we show...

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Source

Identifiers

PMID: 18302931
DOI: 10.1016/j.bbrc.2008.02.090

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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